In New York, Frank worked for magazines and travelled in Europe and South America. He also began using a small 35mm Leica camera, which allowed him to move quickly and photograph people and streets without much preparation.
In 1955, Frank received a Guggenheim Fellowship and set out to photograph the United States. He travelled by car through different parts of the country, photographing cities, small towns, diners, cars, workers, families and political events. He was interested in everyday life, not in the polished image of America often seen in magazines.